تفاعل #67557

معادلة التفاعل

Compound 123

Benzyl 3-(2-propionyloxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate

→

liquid 124

المردود 92.3%

3-(2-propionyloxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid

المردود 92.3%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe catalyst was filtered off
2. 2
   أخرىthe solvent removed under reduced pressure

الإجراء التجريبي

Compound 123 (300 mg, 0.515 mmol) was dissolved in methanol (5 mL) and hydrogenated over Pd/C (30%, 95 mg) under H2 (1 atm) for 3 hr. The catalyst was filtered off and the solvent removed under reduced pressure resulting in the pale-yellow liquid 124 (234 mg, 92%): 1H NMR (400 MHz, CDCl3) δ 1.21 (t, J=7.0, 3H), 1.25 (m, 9H), 1.49 (s, 3H), 1.52 (s, 3H), 2.55-2.68 (m, 4H), 2.72 (AB q, J=13.8, 2H), 3.90-4.13 (m, 6H), 7.15 (dd, J=3.5, 8.1, 1H), 7.67 (ddd, J=1.8, 8.3, 11.8, 1H), 7.84 (dd, J=1.8, 13.7, 1H): 31P (162 MHz, CDCl3) δ 17.53 (d, J=3.7, 1P), 31.82 (d, J=3.7, 1P).

المصدر