تفاعل #67502

معادلة التفاعل

2-cyano-3-fluoro-benzenesulfonyl chloride

thiazolidine

→

2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture is concentrated in vacuo
2. 2
   أخرىPurification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1)
3. 3
   غسيلby acidic washing with a 1M HCl solution

الإجراء التجريبي

440 mg of 2-cyano-3-fluoro-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 0.36 ml of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1) followed by acidic washing with a 1M HCl solution affords 318 mg of 2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile.

المصدر