تفاعل #67493

معادلة التفاعل

water

Et3N

ethyl 3-chloro-3-oxopropionate

decahydroquinoline

→

ethyl 3-(octahydroquinolin-1-yl)-3-oxopropionate

المذيبات

AcOEt

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for 10 h
2. 2
   أخرىthe organic phase is separated
3. 3
   استخلاصthe aqueous phase is extracted once again with AcOEt
4. 4
   غسيلthey are first washed with 5% solution of NaHCO3 and subsequently with brine, they
5. 5
   أخرىare dried over anhydrous

الإجراء التجريبي

3.38 mL of Et3N and 1.44 mL (11 mmol) of ethyl 3-chloro-3-oxopropionate are added to a solution of 1.5 mL (10 mmol) of decahydroquinoline in 100 mL of AcOEt. The resulting solution is kept under stirring at reflux for 10 h. Then water is added and the organic phase is separated, the aqueous phase is extracted once again with AcOEt. The organic phases are pooled and they are first washed with 5% solution of NaHCO3 and subsequently with brine, they are dried over anhydrous

المصدر