تفاعل #674323

معادلة التفاعل

B2

3-[(4-(4,4-Difluoropiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

A1

3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide

rac-2-methoxymethylpiperidine hydrochloride

→

B4

rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide

ظروف التفاعل

المعالجة

1. 1
   أخرىThe title compound was purified by thick-layer chromatography (silica gel, chloroform/MeOH 19:1)
2. 2
   أخرىobtained as a white crystalline solid

الإجراء التجريبي

B4 was prepared following the procedure reported for B2 using A1 and rac-2-methoxymethylpiperidine hydrochloride. The title compound was purified by thick-layer chromatography (silica gel, chloroform/MeOH 19:1) and obtained as a white crystalline solid; yield: 235 mg (67%). MS (ES) C17H24N6O3S requires: 392. found: 393 (M+H)+.

المصدر