تفاعل #674314

معادلة التفاعل

methylphenidate hydrochloride

ammonium hydroxide

→

oil

المردود 95.0%

Methylphenidate

المردود 95.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىformed
2. 2
   استخلاصThe product was extracted with three 100 mL portions of ethyl acetate
3. 3
   تجفيفthe combined organic layers dried over sodium sulfate
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated under reduced pressure at about 40° C.

الإجراء التجريبي

To a 200 mL beaker was charged 10.0 g (37.1 mmol) racemic-methylphenidate hydrochloride and 135 mL water. About 3.39 g (96.8 mmol) ammonium hydroxide was then added to bring the pH to approximately 9 upon which an oily semi-solid formed. The product was extracted with three 100 mL portions of ethyl acetate, the combined organic layers dried over sodium sulfate, filtered and concentrated under reduced pressure at about 40° C. to provide 8.2 g of a clear, colorless viscous oil (95% yield). The IR spectrum of the oil was consistent with the intended product.

المصدر