تفاعل #674296

معادلة التفاعل

tert-Butyl 6-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-azaspiro[3.3]heptane-2-carboxylate

Toluene

→

(±)-5-(1-(2-azaspiro[3.3]heptan-6-yl)-1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine formate

المردود 61.0%

المذيبات

formic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solution was sonicated at room temperature for 1.0 h
2. 2
   تركيزconcentrated by evaporation in vacuo
3. 3
   أخرىto give the residue
4. 4
   أخرىevaporated again
5. 5
   workup.ADDITIONEther (10 mL) was added
6. 6
   ترشيحThe solid was collected by filtration
7. 7
   غسيلwashed with ether (10 mL)
8. 8
   أخرىdried under high vacuum

الإجراء التجريبي

tert-Butyl 6-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)-2-azaspiro[3.3]heptane-2-carboxylate (53 mg, 0.094 mmol) was dissolved in formic acid (3 mL). The solution was sonicated at room temperature for 1.0 h and then concentrated by evaporation in vacuo to give the residue. Toluene (2×5 mL) was added and evaporated again. Ether (10 mL) was added and the mixture was stirred at room temperature for 1.0 h. The solid was collected by filtration, washed with ether (10 mL) and then dried under high vacuum to afford (±)-5-(1-(2-azaspiro[3.3]heptan-6-yl)-1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine formate (29 mg, 61%) as an off-white solid.

المصدر