تفاعل #673003

معادلة التفاعل

8-Bromo-4-methyl-7-trifluoromethyl-3,4,10,10a-tetrahydro-1H-pyrazino[1,2-a]indole-2-carboxylic acid tert-butyl ester

dichloromethane

trifluoroacetic acid

sodium hydroxide

→

title compound

(4R,10aR)-8-Bromo-4-methyl-7-trifluoromethyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indole hydrochloride

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with dichloromethane (3×40 mL)
2. 2
   غسيلwashed with brine
3. 3
   تجفيفdried with MgSO4
4. 4
   أخرىthe solvent was removed in vacuo

الإجراء التجريبي

8-Bromo-4-methyl-7-trifluoromethyl-3,4,10,10a-tetrahydro-1H-pyrazino[1,2-a]indole-2-carboxylic acid tert-butyl ester (0.35 g, 0.8 mmol) were dissolved in dichloromethane (12 mL) and trifluoroacetic acid was added (3 mL). The mixture was stirred for 1 h, added to 1 N sodium hydroxide solution (50 mL) and extracted with dichloromethane (3×40 mL). Organic phases were pooled, washed with brine, dried with MgSO4 and the solvent was removed in vacuo. Chromatography on silica gel (dichloromethane/methanol 19:1) yielded the title compound as a colorless oil which was precipitated as HCl salt from diethylether (0.2 g; 73%). ISP-MS: m/e=335.2, 337.2 (M+H+), α D 20 = - 48.6 .

المصدر