تفاعل #67284

معادلة التفاعل

5-bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxy]phenyl acetate

NaOH

→

crude title compound

[(2S)-7-BROMO-5-FLUORO-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHANOL

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   workup.ADDITIONWater was added
3. 3
   استخلاصthe mixture extracted with EtOAc
4. 4
   غسيلThe combined organic phases were washed with brine
5. 5
   تجفيفdried (Na2SO4)
6. 6
   أخرىevaporated to dryness

الإجراء التجريبي

1-(5-bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxy]phenyl acetate (crude, max 67 mmol) was stirred in dioxane at 0° C. NaOH (15%) was added until the mixture reached pH 14. The mixture was stirred for 30 min at RT and then concentrated. Water was added and the mixture extracted with EtOAc. The combined organic phases were washed with brine, dried (Na2SO4) and evaporated to dryness to give the crude title compound. Yield: 10.3 g. MS m/z (rel. intensity, 70 eV) 262 (M+, bp), 264 (M+, bp), 206 (70), 81 (58), 69 (55), 57 (53).

المصدر