تفاعل #67264

معادلة التفاعل

[7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methanol

p-toluenesulfonyl chloride

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title compound

المردود 74.6%

[7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL 4-METHYLBENZENESULFONATE

المردود 74.6%

المذيبات

DCM

DCM

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with HCl (1 N), water and brine
2. 2
   أخرىThe organic phase was dried
3. 3
   تركيزconcentrated

الإجراء التجريبي

A mixture of [7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methanol (0.9 g, 3.7 mmol), p-toluenesulfonyl chloride (1.0 g, 5.5 mmol), TEA (0.76 ml, 5.5 mmol) and 4-DMAP (0.4 g, 3.7 mmol) in DCM (20 ml) was stirred at room temperature for 1 h and 30 min. The solution was diluted with DCM and washed with HCl (1 N), water and brine. The organic phase was dried and concentrated to give the title compound (1.1 g). MS m/z (rel. intensity, 70 eV) 398 (M+, 51), 226 (bp), 225 (23), 213 (30), 91 (62).

المصدر