تفاعل #67252

ord-c71b1b288cd343e089c69a7a28d1386f

معادلة التفاعل

Cc1ccc(S(=O)(=O)OCC2CCc3ccc(S(C)(=O)=O)cc3O2)cc1
[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate
CC(C)(C)CNC[C@H]1COc2ccc(S(C)(=O)=O)cc2O1
( 2 )
CC(C)(C)CNC[C@H]1COc2ccc(S(C)(=O)=O)cc2O1
2,2-DIMETHYL-N-{[(2S)-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}PROPAN-1-AMINE
CCNC
N-methylethanamine
→
CCN(C)CC1CCc2ccc(S(C)(=O)=O)cc2O1
N-METHYL-N-{[7-(METHYLSULFONYL)-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHYL}ETHANAMINE

المتفاعلات

Cc1ccc(S(=O)(=O)OCC2CCc3ccc(S(C)(=O)=O)cc3O2)cc1
[7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate
—
( 5 )
—
( 4 )
—
( 4 )
CC(C)(C)CNC[C@H]1COc2ccc(S(C)(=O)=O)cc2O1
( 2 )
CC(C)(C)CNC[C@H]1COc2ccc(S(C)(=O)=O)cc2O1
2,2-DIMETHYL-N-{[(2S)-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}PROPAN-1-AMINE
CCNC
N-methylethanamine

الكواشف

لا شيء

المذيبات

CC#N
ACN

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىPreparation

الإجراء التجريبي

Preparation according to Example 25: [7-(methylsulfonyl)-3,4-dihydro-2H-chromen-2-yl]methyl 4-methylbenzenesulfonate (0.020 g, 0.0504 mmol), N-methylethanamine (0.5 ml), ACN (3 ml). MS m/z (rel. intensity, 70 eV) 283 (M+, 2), 131 (4), 77 (4), 73 (5), 72 (bp), 63 (2).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08524766B2uspto-grants-2013_09