تفاعل #67183

معادلة التفاعل

[(2S)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

2-methylpropane-1-amine

→

2-METHYL-N-{[(2R)-7-(METHYLSULFONYL)-2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL]METHYL}PROPAN-1-AMINE

المذيبات

ACN

ظروف التفاعل

المعالجة

1. 1
   أخرىPurification on SCX-3 column (TEA/MeOH) and flash column chromatography (EtOAc/MeOH)
2. 2
   أخرىcrystallized from MeOH/Et2O
3. 3
   أخرى[α]=+65° (MeOH)

الإجراء التجريبي

A mixture of [(2S)-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate (0.2 g, 0.5 mmol), 2-methylpropane-1-amine (1 ml) and ACN (2 ml) was heated under microwave radiation at 120° C. for 30 min. Purification on SCX-3 column (TEA/MeOH) and flash column chromatography (EtOAc/MeOH). Yield: 0.1 g, 77%. The amine was converted to the hydrochloric acid salt and crystallized from MeOH/Et2O. M.p. 213° C. MS m/z (rel. intensity, 70 eV) 299 (M+, 4), 256 (16), 207 (11), 86 (bp), 57 (8). [α]=+65° (MeOH).

المصدر