تفاعل #67154

معادلة التفاعل

N-(2-chloro-5-{4-(5-methyl-1,3,4-oxadiazol-2-yl)-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide

sodium hydroxide

→

title compound

المردود 85.2%

N-{2-Chloro-5-[4-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-indazol-6-yl]-3-pyridinyl}methanesulfonamide

المردود 85.2%

المذيبات

isopropanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed
2. 2
   أخرىthe residue partitioned between water (5 ml) and dichloromethane (5 ml)
3. 3
   استخلاصextracted with dichloromethane (20 ml)
4. 4
   تركيزThe organic layer was concentrated

الإجراء التجريبي

N-(2-chloro-5-{4-(5-methyl-1,3,4-oxadiazol-2-yl)-1-[(4-methylphenyl)sulfonyl]-1H-indazol-6-yl}-3-pyridinyl)methanesulfonamide (16 mg, 0.029 mmol) and 2M sodium hydroxide (1 ml, 2.0 mmol) were placed in isopropanol (5 ml) and the mixture stirred at room temperature overnight. The solvent was removed and the residue partitioned between water (5 ml) and dichloromethane (5 ml). The aqueous was acidified to ˜pH 1 with 2M hydrogen chloride, then extracted with dichloromethane (20 ml). The organic layer was concentrated to give the title compound as a white solid (10 mg).

المصدر