تفاعل #671416

معادلة التفاعل

(3S)-3-ethoxycarbonylmorpholine hydrochloride

propargyl bromide

potassium carbonate

→

(3S)-3-ethoxycarbonyl-4-(2-propynyl)morpholine

المذيبات

N,N-dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solvent was removed under reduced pressure
2. 2
   workup.ADDITIONEthyl acetate and sodium hydrogen carbonate solution were added to the residue
3. 3
   أخرىthe organic layer was separated
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   أخرىevaporated in vacuo
6. 6
   أخرىThe residue was purified by column chromatography on silica gel with a mixture of ethyl acetate and n-hexane (3:7) as an eluent

الإجراء التجريبي

A mixture of (3S)-3-ethoxycarbonylmorpholine hydrochloride (0.3 g), propargyl bromide (0.34 ml) and potassium carbonate (0.91 g) in N,N-dimethylformamide (10 ml) was stirred at room temperature for 1 hour and then the solvent was removed under reduced pressure. Ethyl acetate and sodium hydrogen carbonate solution were added to the residue and the organic layer was separated, dried over magnesium sulfate, and evaporated in vacuo. The residue was purified by column chromatography on silica gel with a mixture of ethyl acetate and n-hexane (3:7) as an eluent to give (3S)-3-ethoxycarbonyl-4-(2-propynyl)morpholine (0.22 g) as an oil.

المصدر