تفاعل #67088

معادلة التفاعل

6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indazole-4-carbonitrile

trimethylsilyl azide

dibutyltin oxide

→

title compound

المردود 34.1%

6-Bromo-1-[(4-methylphenyl)sulfonyl]-4-(1H-tetrazol-5-yl)-1H-indazole

المردود 34.1%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   ترشيحwas collected by filtration
2. 2
   غسيلwashed with toluene
3. 3
   أخرىdried in vacuo at 65° C.

الإجراء التجريبي

A stirred solution of 6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indazole-4-carbonitrile (0.79 g, 2.1 mmol), trimethylsilyl azide (0.484 g, 4.20 mmol) and dibutyltin oxide (0.105 g, 0.420 mmol) in toluene (10 ml) was heated at 110° C. for 1 h in the microwave (biotage initiator). The resulting cream coloured solid was collected by filtration, washed with toluene and dried in vacuo at 65° C. to give the title compound as a near colourless solid (0.3 g). The mother liquor was evaporated and the residue triturated with cyclohexane (10 ml) to give a further quantity of the title compound as a pale yellow solid (0.38 g).

المصدر