تفاعل #66987

معادلة التفاعل

3-phenyl-2-[(Z)-isopropylimino]-thiazolidin-4-one

piperonal

sodium acetate

→

5-benzo[1,3]dioxol-5-ylmeth-(Z)-ylidene-2-[(Z)-isopropylimino]-3-phenyl-thiazolidin-4-one

المذيبات

acetic acid

EA

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with sat. aq. NaHCO3
2. 2
   أخرىevaporated
3. 3
   أخرىThe crude product is purified by crystallisation from a small amount of methanol (approx. 5 mL)

الإجراء التجريبي

A solution of 3-phenyl-2-[(Z)-isopropylimino]-thiazolidin-4-one (150 mg, 0.64 mmol), piperonal (192 mg, 1.28 mmol) and sodium acetate (105 mg, 1.28 mmol) in acetic acid (3 mL) is stirred at 110° C. for 4 h. The dark yellow to brown solution is cooled to rt, diluted with EA (75 mL), washed with sat. aq. NaHCO3, followed by water, and evaporated. The crude product is purified by crystallisation from a small amount of methanol (approx. 5 mL) to give 5-benzo[1,3]dioxol-5-ylmeth-(Z)-ylidene-2-[(Z)-isopropylimino]-3-phenyl-thiazolidin-4-one.

المصدر