تفاعل #66974

معادلة التفاعل

N-Ethylbenzylamine

diisopropylethylamine

Phosgene

→

title compound

Benzyl-ethyl-carbamyl chloride

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   تركيزThe mixture was concentrated
2. 2
   workup.ADDITIONthe residue was diluted with diethyl ether (150 mL)
3. 3
   غسيلwashed twice with H2O
4. 4
   أخرىThe organic layer was dried
5. 5
   تركيزconcentrated

الإجراء التجريبي

N-Ethylbenzylamine (0.56 mL, 3.8 mmol) and diisopropylethylamine (1 mL, 5.7 mmol) were combined in CH2Cl2 (12 mL) and cooled to 0° C. Phosgene (1.9M in toluene; 2.4 mL, 4.6 mmol) was added over 5 minutes, and the reaction was stirred at room temperature overnight. The mixture was concentrated, and the residue was diluted with diethyl ether (150 mL) and washed twice with H2O. The organic layer was dried and concentrated to give the title compound.

المصدر