تفاعل #66952

معادلة التفاعل

3-aminopyrazole

phthalic anhydride

→

title compound

المردود 92.2%

2-(1H-pyrazol-3-yl)-1H-isoindole-1,3(2H)-dione

المردود 92.2%

المذيبات

1,4-dioxane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for 17 hours
2. 2
   أخرىto reach room temperature
3. 3
   أخرىsolvent was evaporated to dryness
4. 4
   غسيلResidue was washed with EtOH
5. 5
   ترشيحa yellowish solid was filtered

الإجراء التجريبي

In a 500 mL round-bottom flask a mixture of 3-aminopyrazole (Aldrich, 10 g, 120 mmol) and phthalic anhydride (Aldrich, 24.96 g, 168 mmol) in 1,4-dioxane (150 mL) was stirred at reflux for 17 hours. The reaction was allowed to reach room temperature and solvent was evaporated to dryness. Residue was washed with EtOH and a yellowish solid was filtered to afford 23.6 g (yield 92%) of the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm: 13.09 (br s, 1H), 7.89-7.98 (m, 4H), 7.86 (br s, 1H), 6.36 (d, 1H). [ES+MS] m/z 214 (MH+).

المصدر