تفاعل #66918

معادلة التفاعل

73

Ethyl 2-(benzyloxy)benzoate

NaOH

EtOH

→

78

المردود 84.6%

2-(Benzyloxy)benzoic acid

المردود 84.6%

المذيبات

H2O

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was reflux for 12 h
2. 2
   ترشيحThe solid was filtered out
3. 3
   أخرىThe precipitate was collected
4. 4
   غسيلwashed with H2O
5. 5
   أخرىThe crude product was recrystallized from

الإجراء التجريبي

To a suspension of 73 (4.0 g, 15.6 mmol) in H2O (150 ml) were added NaOH (3.1 g, 78.0 mmol) and EtOH (5 ml). The mixture was reflux for 12 h, and cooled to 25° C. The solid was filtered out and the filtrate was acidified with 2N HCl. The precipitate was collected and washed with H2O. The crude product was recrystallized from to give 78 as white solid. (3.0 g, 13.2 mmol). Yield: 84.6%; mp 73-75° C.; MS (EI, 70 eV): m/z 228.3 (M+); 1H-NMR (CDCl3, 200 MHz): δ 5.27 (s, 2H), 7.08-7.54 (m, 8H), 6.93 (dd, J=8.0, 1.8 Hz, 1H); 13C-NMR (CDCl3, 50 MHz) δ: 165.43, 157.40, 135.02, 134.34, 133.88, 129.16, 127.92, 122.44, 118.09, 113.11, 72.23; Anal. Calcd for C14H12O3: C, 73.67; H, 5.30.

المصدر