تفاعل #66912

معادلة التفاعل

Compound 22

7-Benzyloxy-2-(2-fluorophenyl)-6-methoxyquinolin-4-one

compound 40

2-(2-Fluorophenyl)-5,6-dihydroxyquinolin-4-one

→

43

المردود 61.3%

2-(2-Fluorophenyl)-7-hydroxy-6-methoxyquinolin-4-one

المردود 61.3%

ظروف التفاعل

المعالجة

1. 1
   أخرىto react in the same manner

الإجراء التجريبي

Compound 22 (0.3 g, 0.80 mmol) was allowed to react in the same manner as described in the preparation of compound 40 to give 43. White solid; yield: 61.3%; mp 277-279° C.; MS (EI, 70 eV): m/z 285 (M+); IR (KBr): 1622.13 (C═O) cm−1; 1H-NMR (DMSO-d6 200 MHz): δ 3.82 (s, 3H), 6.04 (s, 1H), 7.01 (s, 1H), 7.32-7.50 (m, 3H), 7.50-7.67 (m, 2H), 10.22 (s, 1H), 11.68 (s, 1H); 13C-NMR (DMSO-d6, 50 MHz): δ 55.52, 102.72, 105.37, 108.20, 116.28 (d, J=22.5 Hz), 118.07, 122.94, 124.92, 130.75, 131.99 (d, J=7.95 Hz), 136.45, 143.61, 146.58, 151.59, 158.98 (d, J=246.9 Hz), 175.30; Anal. calcd for C16H12FNO3: C, 67.36; H, 4.24; N, 4.91. Found: C, 67.37; H, 4.26; N, 4.90.

المصدر