تفاعل #66905

معادلة التفاعل

4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-5,6,7,8-tetrahydrothieno[2,3-b:5,4-c′]dipyridine-3-carbonitrile

(2E)-4-[methyl(1-methylethyl)amino]but-2-enoic acid hydrochloride

DIPEA

TBTU

→

title compound

المردود 61.3%

4-({3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-7-{(2E)-4-[methyl(1-methylethyl)amino]but-2-enoyl}-5,6,7,8-tetrahydrothieno[2,3-b:5,4-c′]dipyridine-3-carbonitrile

المردود 61.3%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىdirectly purified by preparative HPLC

الإجراء التجريبي

A solution of 4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)-5,6,7,8-tetrahydrothieno[2,3-b:5,4-c′]dipyridine-3-carbonitrile from Example 90A (80 mg, 0.17 mmol) and (2E)-4-[methyl(1-methylethyl)amino]but-2-enoic acid hydrochloride from Example 2A (47 mg, 0.24 mmol) in DMF (2 mL) was treated with DIPEA (89 mg, 0.69 mmol) and TBTU (83 mg, 0.26 mmol). The mixture was stirred at rt overnight and then directly purified by preparative HPLC to yield 63 mg (61%) of the title compound.

المصدر