تفاعل #66888

معادلة التفاعل

(2E)-4-bromobut-2-enoic acid

3-chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

3-Chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

3-azabicyclo[3.2.1]-octane

→

title compound

3-({7-[(2E)-4-(3-Azabicyclo[3.2.1]oct-3-yl)but-2-enoyl]-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-yl}amino)-5-chlorophenol

ظروف التفاعل

المعالجة

1. 1
   أخرىto yield 44 mg (32%)

الإجراء التجريبي

In analogy to Example 130, the title compound was prepared from (2E)-4-bromobut-2-enoic acid (84 mg, 0.41 mmol), 3-chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 65A (100 mg, 0.27 mmol) and 3-azabicyclo[3.2.1]-octane (48 mg, 0.43 mmol) to yield 44 mg (32%).

المصدر