تفاعل #668641

معادلة التفاعل

trimethylsilanylethyl 2-fluoro-4-iodobenzoate

Compound D

trimethylsilanylethyl 2-fluoro-4-iodobenzoate

4-vinylbenzoic acid

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title compound

Ethyl 4-vinylbenzoate

ظروف التفاعل

الإجراء التجريبي

Employing the same general procedure as for the preparation of trimethylsilanylethyl 2-fluoro-4-iodobenzoate (Compound D), 323 mg (2.2 mmol) of 4-vinylbenzoic acid was converted into the title compound using 462 mg (2.4 mmol) of 1-(3-dimethylaminopropyl-3-ethyl carbodiimide hydrochloride), 264 mg (2.2 mmol) of 4-dimethylaminopyridine, 0.32 ml (250 mg, 5.45 mmol) of ethanol and 16 mL of dichloromethane. Purification by flash chromatography (silica, 10% ethyl acetate in hexane) gave the title compound as a clear, colorless oil.

المصدر