تفاعل #66855

معادلة التفاعل

suspension

7-[(2E)-4-Chlorobut-2-enoyl]-N-(3,4-dichlorophenyl)-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-amine

1-methyloctahydropyrrolo[3,4-b]pyrrole

→

N-(3,4-Dichlorophenyl)-7-[(2E)-4-(1-methylhexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)but-2-enoyl]-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-amine

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter purification by preparative HPLC
2. 2
   أخرىthe title compound was crystallized from dichloromethane/petroleum ether
3. 3
   أخرىto yield 12 mg (14%)

الإجراء التجريبي

To a suspension of Example 59A (80 mg, 0.16 mmol) in DMF (1 mL) was added 1-methyloctahydropyrrolo[3,4-b]pyrrole (41 mg, 0.32 mmol), and the mixture was stirred at rt for 20 h. After purification by preparative HPLC, the title compound was crystallized from dichloromethane/petroleum ether to yield 12 mg (14%).

المصدر