تفاعل #6673

معادلة التفاعل

phenothiazine

iodoethane

potassium hydroxide

→

10-Ethylphenothiazine

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed for 24 hours
2. 2
   درجة الحرارةAfter cooling
3. 3
   ترشيحthe reaction mixture was filtered
4. 4
   أخرىthe solvent was evaporated
5. 5
   أخرىThe product was crystallized from methanol

الإجراء التجريبي

A mixture of 10 g (0.05 mol) of phenothiazine, 11.7 g (0.075 mol) of iodoethane, 4.2 g (0.075 mol) of potassium hydroxide and 0.25 g of tetra-n-butylammonium hydrogen sulfate in 200 ml of dry toluene was refluxed for 24 hours. After cooling, the reaction mixture was filtered, and the solvent was evaporated. The product was crystallized from methanol. The yield of 10-ethylphenothiazine (C14H13NS, FW=227.33) was 90%.

المصدر