تفاعل #66699

معادلة التفاعل

2-(1-Hydroxy-1-methyl-ethyl)-4-methoxy-5-piperazin-1-yl-phenol

trifluoroacetic acid

triethyl silane

→

2-Isopropyl-4-methoxy-5-piperazin-1-yl-phenol

المردود 99.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىwas evaporated under reduced pressure
2. 2
   أخرىThe residue was partitioned between dichloromethane and saturated aqueous potassium carbonate
3. 3
   أخرىThe organic layer was separated
4. 4
   غسيلwashed with water
5. 5
   تجفيفdried (MgSO4)
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated under reduced pressure

الإجراء التجريبي

To a stirred suspension of 2-(1-Hydroxy-1-methyl-ethyl)-4-methoxy-5-piperazin-1-yl-phenol (0.5 g, 1.9 mmol) in dichloromethane under nitrogen at room temperature was added trifluoroacetic acid (7.2 mL, 93.86 mmol) followed by triethyl silane (3.0 mL, 18.8 mmol). The reaction mixture was stirred for 18 hours at room temperature, and then was evaporated under reduced pressure. The residue was partitioned between dichloromethane and saturated aqueous potassium carbonate. The organic layer was separated, washed with water, dried (MgSO4), filtered, and evaporated under reduced pressure to afford 0.47 g (99%) of 2-Isopropyl-4-methoxy-5-piperazin-1-yl-phenol as an oil.

المصدر