تفاعل #66690

معادلة التفاعل

2-Chloro-N-(2-hydroxy-4-methoxy-phenyl)-acetamide

potassium carbonate

→

7-Methoxy-4H-benzo[1,4]oxazin-3-one

المردود 101.0%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction mixture was refluxed under nitrogen for eight hours
2. 2
   درجة الحرارةThe reaction mixture was cooled
3. 3
   أخرىsolids were removed by filtration
4. 4
   تركيزthe liquid was concentrated under reduced pressure

الإجراء التجريبي

2-Chloro-N-(2-hydroxy-4-methoxy-phenyl)-acetamide (390.0 g, 0.18 mol) and powdered potassium carbonate (27.6 g, 0.2 mol) were added to 1000 mL acetone, and the reaction mixture was refluxed under nitrogen for eight hours. The reaction mixture was cooled, solids were removed by filtration, and the liquid was concentrated under reduced pressure to give 32.56 g of crude 7-Methoxy-4H-benzo[1,4]oxazin-3-one. (M+H)=180.

المصدر