تفاعل #66672

معادلة التفاعل

2-Isopropyl-4-methoxy-1-(toluene-4-sulfonyl)-benzene

ICl

NaHCO3

→

1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene

المردود 91.8%

المذيبات

HOAc

HOAc

H2O

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe aqueous solution was extracted into EtOAc which
2. 2
   غسيلwas washed with water, brine
3. 3
   تجفيفdried over Na2SO4
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated in vacuo

الإجراء التجريبي

To a solution of 2-Isopropyl-4-methoxy-1-(toluene-4-sulfonyl)-benzene (10 g, 31.25 mmol) in HOAc (10 ml) was added a solution of ICl (9.6 g, 59.26 mmol) in HOAc (10 ml) and H2O (5 ml). The reaction mixture was stirred at room temperature for 16 hrs and basified by saturated NaHCO3 solution. The aqueous solution was extracted into EtOAc which was washed with water, brine, dried over Na2SO4, filtered and concentrated in vacuo to give 1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene (12.35 g, 89%).

المصدر