تفاعل #66653

معادلة التفاعل

NH3

4-Chloro-5-(5-chloro-2-isopropyl-4-methoxy-benzyl)-2-methylsulfanyl-pyrimidine

→

5-(5-chloro-2-isopropyl-4-methoxy-benzyl)-2-methylsulfanyl-pyrimidin-4-ylamine

المردود 92.0%

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter 3 days the solution was cooled
2. 2
   تركيزconcentrated in vacuo
3. 3
   ترشيحThe precipitate was filtered
4. 4
   تركيزthe mother liquor was concentrated in vacuo
5. 5
   أخرىPurification via flash chromatography (7:3 hexane/ethyl acetate)

الإجراء التجريبي

To 25 ml of saturated NH3 in EtOH was added 4-Chloro-5-(5-chloro-2-isopropyl-4-methoxy-benzyl)-2-methylsulfanyl-pyrimidine (0.580 g, 1.6 mmol). The solution was warmed to 85° C. in a sealed reaction vessel. After 3 days the solution was cooled, concentrated in vacuo and suspended in CH2Cl2. The precipitate was filtered and the mother liquor was concentrated in vacuo. Purification via flash chromatography (7:3 hexane/ethyl acetate) afforded 5-(5-chloro-2-isopropyl-4-methoxy-benzyl)-2-methylsulfanyl-pyrimidin-4-ylamine (0.504 g, 92%) as a white solid.

المصدر