تفاعل #66519

معادلة التفاعل

2-Chloro-1-fluoro-4-nitrobenzene

3-chlorophenol

Cs2CO3

→

2-chloro-1-(3-chlorophenoxy)-4-nitrobenzene

المردود 100.0%

المذيبات

DMF ACN

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was quenched with water
2. 2
   استخلاصThe aqueous phase was extracted with AcOEt
3. 3
   غسيلThe organic phase was washed with brine
4. 4
   تجفيفwas dried over MgSO4
5. 5
   ترشيحwas filtered
6. 6
   تركيزwas concentrated under reduced pressure
7. 7
   أخرىThe crude product was used without further purification

الإجراء التجريبي

According to Scheme 3 Step 1, Method A: 2-Chloro-1-fluoro-4-nitrobenzene (1.12 mmol, 0.20 g) was added to a suspension of 3-chlorophenol (1.02 mmol, 0.10 mL), Cs2CO3 (1.25 mmol, 407 mg) in DMF/ACN (40:60, 3.6 mL). The reaction mixture was stirred at room temperature overnight. The reaction mixture was quenched with water. The aqueous phase was extracted with AcOEt. The organic phase was washed with brine, was dried over MgSO4, was filtered and was concentrated under reduced pressure. The crude product was used without further purification to obtain 2-chloro-1-(3-chlorophenoxy)-4-nitrobenzene (1.02 mmol, 288 mg, 100%) as an orange solid.

المصدر