تفاعل #66516

معادلة التفاعل

thiophene-2-carbonyl chloride

3-methoxyaniline

DIEA

→

N-(3-methoxyphenyl)thiophene-2-carboxamide

المردود 70.1%

المذيبات

DCM

DCM

ظروف التفاعل

المعالجة

1. 1
   غسيلThe organic phase was washed with HCl 1 M solution
2. 2
   تجفيفwith a saturated solution of NaHCO3, was dried over MgSO4
3. 3
   ترشيحwas filtered
4. 4
   تركيزwas concentrated under reduced pressure

الإجراء التجريبي

According to Scheme 1 Method A: A solution of thiophene-2-carbonyl chloride (2.92 mmol, 0.31 mL) in DCM (1 mL) was added to solution of 3-methoxyaniline (2.44 mmol, 0.27 mL) and DIEA (4.87 mmol, 0.87 mL) in DCM (4 mL) at 0° C. The reaction mixture was stirred at room temperature for 1 hour. The organic phase was washed with HCl 1 M solution, then with a saturated solution of NaHCO3, was dried over MgSO4, was filtered and was concentrated under reduced pressure to yield N-(3-methoxyphenyl)thiophene-2-carboxamide (1.71 mmol, 0.40 g, 70%) as a white solid.

المصدر