تفاعل #66513

معادلة التفاعل

4-iodo-1H-pyrazole

1-(chloromethyl)-4-methoxybenzene

K2CO3

→

4-iodo-1-(4-methoxybenzyl)-1H-pyrazole

المردود 88.2%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was cooled to room temperature
2. 2
   ترشيحwas filtered
3. 3
   تركيزThe filtrate was concentrated under reduced pressure
4. 4
   أخرىThe crude product was purified by flash chromatography over silica gel

الإجراء التجريبي

According to Scheme 6 Step 1: A suspension of 4-iodo-1H-pyrazole (26.3 mmol, 5.11 g), 1-(chloromethyl)-4-methoxybenzene (29.0 mmol, 3.95 mL) and K2CO3 (39.5 mmol, 5.46 g) in acetonitrile (150 mL) was heated at 60° C. overnight. The reaction mixture was cooled to room temperature and was filtered. The filtrate was concentrated under reduced pressure. The crude product was purified by flash chromatography over silica gel using DCM as eluent to afford 4-iodo-1-(4-methoxybenzyl)-1H-pyrazole (23.2 mmol, 7.3 g, 88%) as a yellow solid.

المصدر