تفاعل #66396

معادلة التفاعل

tert-butyl(trans)-2-(1,1′-biphenyl-4-yl)cyclopropyl(2-(4-methylpiperazin-1-yl)-2-oxoethyl)carbamate

Et2O.HCl

→

2-((trans)-2-(1,1′-biphenyl-4-yl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone

المردود 15.0%

المذيبات

Et2O

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter completion reaction mixture
2. 2
   ترشيحwas filtered under inert atmosphere
3. 3
   غسيلwashed with hexane and EtOAC
4. 4
   أخرىdried under reduced pressure

الإجراء التجريبي

To a solution of tert-butyl(trans)-2-(1,1′-biphenyl-4-yl)cyclopropyl(2-(4-methylpiperazin-1-yl)-2-oxoethyl)carbamate derivative (1 equiv) in Et2O at 0° C. was added Et2O.HCl slowly drop wise, stirred for 1 h at 0° C. to RT. The progress of the reaction was monitored by TLC. After completion reaction mixture was filtered under inert atmosphere and washed with hexane and EtOAC, and dried under reduced pressure to get 2-((trans)-2-(1,1′-biphenyl-4-yl)cyclopropylamino)-1-(4-methylpiperazin-1-yl)ethanone derivative (Overall yield 15%).

المصدر