تفاعل #66119

معادلة التفاعل

p-nitro-phenol

potassium carbonate

1,2-dibromoethane

→

1-(2-bromo-ethoxy)-4-nitro-benzene

المردود 70.7%

المذيبات

butanone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux for 18 h
3. 3
   درجة الحرارةThe mixture was cooled
4. 4
   ترشيحthe inorganic salts filtered
5. 5
   تركيزthe filtrate concentrated under vacuum
6. 6
   أخرىto give a brown viscous liquid, which
7. 7
   أخرىwas partitioned between dichloromethane and water
8. 8
   أخرىThe organic phase was separated
9. 9
   تركيزconcentrated in vacuo
10. 10
    أخرىto obtain a residue which
11. 11
    أخرىwas purified by column chromatography

الإجراء التجريبي

A mixture of p-nitro-phenol (6.0 g, 43.1 mmol), potassium carbonate (14.9 g, 108 mmol) and 1,2-dibromoethane (24.3 g, 129 mmol) in butanone (80 mL) was heated at reflux for 18 h. The mixture was cooled, the inorganic salts filtered and the filtrate concentrated under vacuum to give a brown viscous liquid, which was partitioned between dichloromethane and water. The organic phase was separated and concentrated in vacuo to obtain a residue which was purified by column chromatography using 4% ethyl acetate in petroleum ether as eluent to afford 1-(2-bromo-ethoxy)-4-nitro-benzene (7.5 g, 70%) as a light yellow solid.

المصدر