تفاعل #660891

ord-e78bf50f3ba74f6dadb1b47cec69d7a7

معادلة التفاعل

CC(C)c1nc2c(c(I)c1C=O)[C@@H](O[Si](C)(C)C(C)(C)C)CC(C)(C)C2
(S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde
CC(F)(F)c1ccc(I)cc1
1-(1,1-difluoroethyl)-4-iodobenzene
→
CC(C)c1nc2c(c(I)c1[C@@H](O)c1ccc(C(C)(F)F)cc1)[C@@H](O[Si](C)(C)C(C)(C)C)CC(C)(C)C2
(S)—((S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-(1,1-difluoroethyl)phenyl)methanol

المتفاعلات

CC(C)c1nc2c(c(I)c1C=O)[C@@H](O[Si](C)(C)C(C)(C)C)CC(C)(C)C2
(S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde
CC(F)(F)c1ccc(I)cc1
1-(1,1-difluoroethyl)-4-iodobenzene

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىObtained

الإجراء التجريبي

Obtained by starting from (S)-5-(tert-butyldimethylsilyloxy)-4-iodo-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinoline-3-carbaldehyde and 1-(1,1-difluoroethyl)-4-iodobenzene.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US09029544B2uspto-grants-2015_05