تفاعل #66056

معادلة التفاعل

HCl

2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole

HCl

2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole

→

2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride salt

المذيبات

isopropyl acetate

IPAC

ظروف التفاعل

المعالجة

1. 1
   أخرىHCl (gas) may be bubbled into the slurry for about 1 hour
2. 2
   ترشيحafter which the mixture may be filtered
3. 3
   غسيلwashed with IPAC
4. 4
   أخرىdried under vacuum at room temperature

الإجراء التجريبي

An alternate method for conversion of the sulfonate or halide salts of 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole to an HCl salt involves the use of a concentrated solution of HCl and isopropyl acetate (IPAC). A sulfonate or halide salt of 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole may be taken up in IPAC and cooled to 15° C. HCl (gas) may be bubbled into the slurry for about 1 hour, after which the mixture may be filtered, washed with IPAC and dried under vacuum at room temperature to afford a 2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride salt. A detailed example of this synthesis may be found in Example 9.

المصدر