تفاعل #66050

معادلة التفاعل

96

Methyl (2S)-2-acetamido-3-(4-[9-anthracenyl]phenyl)-propanoate

lithium hydroxide monohydrate

→

title compound

المردود 90.0%

(2S)-2-Acetamido-3-(4-[9-anthracenyl]phenyl) propanoic acid

المردود 90.0%

المذيبات

water

THF water

ظروف التفاعل

المعالجة

1. 1
   أخرىthe THF was removed by evaporation
2. 2
   غسيلThe aqueous layer was washed with DCM (40 mL)
3. 3
   أخرىto remove unreacted
4. 4
   استخلاصthe resulting precipitate was extracted with DCM (3×40 mL)
5. 5
   أخرىThe combined organics were dried
6. 6
   أخرىevaporated

الإجراء التجريبي

To a solution of 96 (80 mg, 0.20 mmol) in THF/water, 2:1 (3 mL) was added lithium hydroxide monohydrate (17 mg, 0.40 mmol) and the resulting suspension was allowed to stir for 16 h. The reaction mixture was diluted with water (30 mL) and the THF was removed by evaporation. The aqueous layer was washed with DCM (40 mL) to remove unreacted starting material. The aqueous phase was acidified with 10% HCl and the resulting precipitate was extracted with DCM (3×40 mL). The combined organics were dried and evaporated to yield the title compound (69 mg, 0.18 mmol, 90%) as a white solid. Mp 76° C. [α]D20 +29.7 (c. 0.1, EtOH). 1H NMR (CDCl3, 300 MHz): δ 8.47 (s, 1H, ArH10″); 8.02 (d, J=8.4 Hz, 2H, ArH3″ and ArH6″); 7.59 (d, J=8.7 Hz, 2H, ArH8″ and ArH1″); 7.45 (m, 2H, ArH4″ and ArH5″); 7.35 (m, 6H, ArH2″ and ArH7″, 4×ArH″); 6.27 (d, J=6.6 Hz, 1H, NH); 5.00 (m, 1H, H2); 3.39 (dd, J=4.8, 12.9 Hz, 1H, H3a); 3.26 (dd, J=6.3, 14.4 Hz, 1H, H3b); 2.07 (s, 3H, COCH3). Mass Spectrum (ES, +ve) m/z 383 (70%) [MH+]. HRMS calcd for C25H22NO3 384.1600, found 384.1610.

المصدر