تفاعل #6602

معادلة التفاعل

aluminum chloride

phenol

2,5-dichloro-2,5-dimethylhexane

→

title compound

المردود 32.1%

5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthol

المردود 32.1%

المذيبات

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ether
2. 2
   غسيلthe organic phase was washed
3. 3
   تجفيفdried over sodium sulfate
4. 4
   أخرىevaporated under reduced pressure
5. 5
   أخرىTwo recrystallizations of the residue from methanol

الإجراء التجريبي

27.5 g (0.2 mol) of anhydrous aluminum chloride were added by spatula to 250.0 g (2.65 mol) of phenol plus 414.5 g (2.27 mol) of 2,5-dichloro-2,5-dimethylhexane in 500 ml of petroleum ether at room temperature while stirring. After 48 hours, the reaction mixture was poured into ice-water and extracted with ether, and the organic phase was washed to neutrality with water, dried over sodium sulfate and evaporated under reduced pressure. Two recrystallizations of the residue from methanol yielded 148.7 g of the title compound of melting point 219°-220 C.

المصدر