تفاعل #65894

معادلة التفاعل

compound D

5-(4'-methylbiphenyl-2-yl)-1-(4-nitrophenyl)-1H-tetrazole

N-bromosuccinimide

→

5-(4'-bromomethylbiphenyl-2-yl)-1-(4-nitrophenyl)-1H-tetrazole

المردود 79.7%

المذيبات

methyl chloroform

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux for 4 hours
3. 3
   غسيلwashed with water (3×50 ml)
4. 4
   ترشيحthe suspended solid collected by filtration

الإجراء التجريبي

A mixture of compound D (8.0 g; 21 mmol), N-bromosuccinimide (4.53 g; 25 mmol) and azo(bisisobutyronitrile) (73 mg) in methyl chloroform (50 ml) was heated at reflux for 4 hours. The mixture was cooled to ambient temperature, washed with water (3×50 ml), and the suspended solid collected by filtration to give 5-(4'-bromomethylbiphenyl-2-yl)-1-(4-nitrophenyl)-1H-tetrazole (E) (7.3 g), m.p 192°-195° C.; NMR (CDCl3): 4.4(2H, s), 6.52(2H, d), 6.85(2H, d), 7.07(2H, d), 7.4(1H, d), 7.7(2H, m), 7.9(1H, d).

المصدر