تفاعل #658589

معادلة التفاعل

6-chloro-3-cyclobutyl-1-trityl-1H-pyrazolo[4,3-c]pyridine

1-butylurea

Xantphos

Cs2CO3

TFA

→

1-butyl-3-(3-cyclobutyl-1H-pyrazolo[4,3-c]pyridin-6-yl)urea

المذيبات

dioxane

ظروف التفاعل

الإجراء التجريبي

In a manner similar to that described in Scheme 6 and Example 30, 6-chloro-3-cyclobutyl-1-trityl-1H-pyrazolo[4,3-c]pyridine was reacted with 1-butylurea, (Xantphos, Pd(OAc)2, Cs2CO3, dioxane, 80° C., overnight) and then deprotected with TFA to provide 1-butyl-3-(3-cyclobutyl-1H-pyrazolo[4,3-c]pyridin-6-yl)urea. MS ESI calc'd. for C15H21N5O[M+1]+ 288, found 288.

المصدر