تفاعل #65831

معادلة التفاعل

3-methoxy-3-[3-(naphth-2-ylmethoxy)phenyl]pyrrolidine

2-chloroacetonitrile

→

1-(cyanomethyl)-3-methoxy-3-[3-(naphth-2-ylmethoxy)phenyl]pyrrolidine

المردود 45.0%

ظروف التفاعل

الإجراء التجريبي

Using an analogous procedure to that described in Example 3, 3-methoxy-3-[3-(naphth-2-ylmethoxy)phenyl]pyrrolidine was reacted with 2-chloroacetonitrile to give 1-(cyanomethyl)-3-methoxy-3-[3-(naphth-2-ylmethoxy)phenyl]pyrrolidine in 45% yield, m.p. 76°-77° C. (recrystallised from methanol).

المصدر