تفاعل #65801

معادلة التفاعل

1-(2-bromocyclopenten-1-yl)-4-(methylthio) benzene

1-(2-bromocyclopenten-1-yl)-4-(methylthio)benzene

2,4-dichlorophenylboronic acid

→

1-[2-(2,4-dichlorophenyl)cyclopenten-1-yl]-4-(methylthio)benzene

المردود 89.8%

ظروف التفاعل

المعالجة

1. 1
   أخرىPurification by silica gel chromatography (MPLC) with hexane

الإجراء التجريبي

Following the synthetic procedure outlined in Step 3 of Example 1, 280 mg (0.93 mmol) of 1-(2-bromocyclopenten-1-yl)-4-(methylthio) benzene (Example 1, Step 2) was reacted with 350 mg (1.9 mmol) of 2,4-dichlorophenylboronic acid (Lancaster). Purification by silica gel chromatography (MPLC) with hexane gave 280 mg of 1-[2-(2,4-dichlorophenyl)cyclopenten-1-yl]-4-(methylthio)benzene as an oil: NMR (CDCl3) d 2.10 (m, J=7 Hz, 2H), 2.41 (s, 3H), 2.81 (t, J=8 Hz, 4H), 2.92 (m, J=8 Hz, 2H), 6.95-7.21 (m, 6H), 7.40 (s, 1H).

المصدر