تفاعل #65792

معادلة التفاعل

3-amino-4,5-dimethoxycarbonyl-6-methoxy-2-methylpyridine

hydrazine monohydrate

→

8-Amino-5-methoxy-7-methylpyrido[3,4-d]pyridazine-1,4(2H,3H)dione

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was refluxed
2. 2
   ترشيحThe resulting crystals were collected by filtration
3. 3
   غسيلwashed with methanol
4. 4
   ترشيحThe crystals were collected by filtration
5. 5
   غسيلwashed with water

الإجراء التجريبي

In 8 ml of methanol was dissolved 280 mg of 3-amino-4,5-dimethoxycarbonyl-6-methoxy-2-methylpyridine, and then 0.54 ml (10 eq.) of hydrazine monohydrate was added to the solution. The mixture was refluxed. The resulting crystals were collected by filtration and washed with methanol. The crystals were suspended in water, and the suspension was acidified with hydrochloric acid. The crystals were collected by filtration and washed with water.

المصدر