تفاعل #65764

معادلة التفاعل

3-amino-4,5-diethoxycarbonyl-2-methylpyridine

hydrazine monohydrate

→

8-Amino-7-methylpyrido[3,4-d]pyridazine-1,4(2H,3H)dione

ظروف التفاعل

المعالجة

1. 1
   workup.DISTILLATIONAfter the solvent was distilled off
2. 2
   ترشيحthe resulting crystals were collected by filtration with ethanol
3. 3
   workup.ADDITIONWater was added to the crystals
4. 4
   ترشيحfollowed by collection of the crystals by filtration

الإجراء التجريبي

To 57 mg of 3-amino-4,5-diethoxycarbonyl-2-methylpyridine was added 0.5 mL of hydrazine monohydrate, and the mixture was heated at 100° C. in a stream of nitrogen for 30 minutes. After the solvent was distilled off, the resulting crystals were collected by filtration with ethanol. Water was added to the crystals, and the mixture was neutralized with 1N hydrochloric acid, followed by collection of the crystals by filtration.

المصدر