تفاعل #65749

معادلة التفاعل

3-amino-4,5-dimethoxycarbonyl-6-methoxy-2-phenylpyridine

hydrazine monohydrate

hydrochloric acid

→

8-Amino-5-methoxy-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)dione

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةUnder ice-cooling
2. 2
   ترشيحThe resulting yellow crystalline precipitate was collected by filtration

الإجراء التجريبي

To 0.8 g of 3-amino-4,5-dimethoxycarbonyl-6-methoxy-2-phenylpyridine was added 4 ml of hydrazine monohydrate. The mixture was heated at 100° C. in a stream of nitrogen for 1 hour. Under ice-cooling, water was added to the reaction mixture, followed by neutralization with hydrochloric acid for adjustment to pH 3. The resulting yellow crystalline precipitate was collected by filtration.

المصدر