تفاعل #65735

معادلة التفاعل

5-(trifluoromethyl)-5-methylpyrrolidin-2-one

triethylamine

anisoyl chloride

→

N-(4-methoxyphenylcarbonyl)-5-(trifluoromethyl)-5-methylpyrrolidin-2-one

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solid which precipitates
2. 2
   ترشيحis filtered off with suction
3. 3
   غسيلthe salt is washed with a little dioxane
4. 4
   أخرىthe organic phase is separated off with the addition of a little methylene chloride
5. 5
   أخرىis recrystallized from ligroin

الإجراء التجريبي

5.0 g (0.03 mol) of 5-(trifluoromethyl)-5-methylpyrrolidin-2-one in 10 ml of dioxane are stirred with 3.3 g of triethylamine and 6.8 g (0.04 mol) of anisoyl chloride for 16 h at 110°-120° C. The solid which precipitates is filtered off with suction and the salt is washed with a little dioxane. The dioxane solution is stirred into 50 ml of water and the organic phase is separated off with the addition of a little methylene chloride. After stripping off the solvent, the residue is a brownish solid which is recrystallized from ligroin.

المصدر