تفاعل #657349

معادلة التفاعل

5-methoxyanthranilic acid

acetic anhydride

→

title compound

المردود 77.0%

2-methyl-6-(methyloxy)-4H-3,1-benzoxazin-4-one

المردود 77.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةbefore being cooled
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   تركيزThe crude residue was then concentrated twice in the presence of toluene
4. 4
   ترشيحbefore being filtered
5. 5
   غسيلwashed with ether

الإجراء التجريبي

A solution of 5-methoxyanthranilic acid (7.8 g, 46.5 mmol) was refluxed in acetic anhydride (60 mL) for 2 h15 before being cooled and concentrated under reduced pressure. The crude residue was then concentrated twice in the presence of toluene before being filtered and washed with ether to yield to the title compound (6.8 g, 77% yield) as a beige solid; LC/MS: m/z 192 [M+H]+, Rt 1.69 min.

المصدر