تفاعل #657271

معادلة التفاعل

(2,6-Dimethyl-piperidin-1-yl)-acetic acid hydrochloride

(2,6-Dimethyl-piperidine-1-yl)-acetic acid hydrochloride

N-hydroxysuccinimide

→

(2,6-Dimethyl-piperidine-1-yl)-acetic acid-(2,5-dioxo-pyrrolidine-1-yl)-ester

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe residue was filtered
2. 2
   أخرىthe filtrate was evaporated in vacuo to dryness
3. 3
   workup.DISSOLUTIONAfter dissolving the residue in 300 ml CH2Cl2
4. 4
   غسيلthe solution was washed with NaHCO3
5. 5
   تجفيفdried over sodium sulphate
6. 6
   أخرىthe solvent was evaporated
7. 7
   أخرىThe compound was then recrystallised from diisopropylether (activated charcoal)

الإجراء التجريبي

12.60 g (60 mMol) (2,6-Dimethyl-piperidin-1-yl)-acetic acid hydrochloride (5), in 100 ml DMF, was added to 7.02 g (60 mMol) N-hydroxysuccinimide and 12.58 g (60 mMol) N,N-dicyclohexylcarbodiimide. The reaction mixture was stirred for 16 h at RT. The residue was filtered and the filtrate was evaporated in vacuo to dryness. After dissolving the residue in 300 ml CH2Cl2, the solution was washed with NaHCO3, dried over sodium sulphate and the solvent was evaporated. The compound was then recrystallised from diisopropylether (activated charcoal).

المصدر