تفاعل #657257

معادلة التفاعل

1-trityl-4-ethoxymethylpyrazole

→

4-ethoxymethylpyrazole

المردود 44.0%

المذيبات

ethanol acetone

HCl

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added to the resulting solution
2. 2
   درجة الحرارةAfter cooling to room temperature
3. 3
   ترشيحthe reaction mixture was filtered
4. 4
   غسيلwashed with dichloromethane
5. 5
   استخلاصextracted with dichloromethane
6. 6
   تجفيفdried over MgSO4
7. 7
   أخرىthe solvent was evaporated under vacuum

الإجراء التجريبي

1-trityl-4-ethoxymethylpyrazole (1.800 g, 4.88 mmol) was dissolved in a mixture of ethanol/acetone (15 ml/5 ml) and 30 mL of 2N HCl was added to the resulting solution. The mixture was heated at 80° C. for 2 h. After cooling to room temperature, the reaction mixture was filtered and washed with dichloromethane. The aqueous layer was basified with 2N NaOH and extracted with dichloromethane. The organic layers were combined, dried over MgSO4 and the solvent was evaporated under vacuum yielding compound 4-ethoxymethylpyrazole as a white oil. Yield: 44% (270 mg, 2.14 mmol).

المصدر