تفاعل #65723

معادلة التفاعل

6-Chloronicotinic acid

hydrazine hydrate

→

pale brown solid

المردود 77.0%

6-Hydrazinopyridine-3-Carboxylic Acid

المردود 77.0%

المذيبات

water

hydrochloric acid

ظروف التفاعل

المعالجة

1. 1
   أخرىwas placed in a 100° C.
2. 2
   أخرىfor 4 hours
3. 3
   تركيزThe homogeneous reaction mixture was concentrated to dryness
4. 4
   أخرىto give a white solid
5. 5
   أخرىformed
6. 6
   أخرىThe precipitate was isolated by filtration
7. 7
   غسيلthe solid was washed with 95% ethanol and ether

الإجراء التجريبي

6-Chloronicotinic acid (8.0g) was added to 85% hydrazine hydrate (35 ml). The reaction mixture was placed in a 100° C. oil bath for 4 hours. The homogeneous reaction mixture was concentrated to dryness to give a white solid. The solid was dissolved in water and on acidification to pH 5.5 with concentrated hydrochloric acid a precipitate formed. The precipitate was isolated by filtration and the solid was washed with 95% ethanol and ether to give 6.0 g of a pale brown solid; yield 77% m.p. 292°-293° C.;

المصدر