تفاعل #656787

معادلة التفاعل

dichloromethyl 2-(p-chlorophenoxy)-ethyl ether

triethyl phosphite

ethyl chloride

→

Tetraethyl [2-(p-chlorophenoxy)-ethoxymethylene]-bisphosphonate

المذيبات

ether

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was cooled
2. 2
   غسيلwashed with aqueous sodium bicarbonate
3. 3
   أخرىdried
4. 4
   أخرىevaporated
5. 5
   أخرىUnreacted triethyl phosphite was removed in vacuo
6. 6
   أخرىthe crude product was used in the next step without further purification

الإجراء التجريبي

Anhydrous zinc chloride (10 g) was added at 150° C. to a mixture of dichloromethyl 2-(p-chlorophenoxy)-ethyl ether (5.1 g) and triethyl phosphite (6.9 ml). When the evolution of ethyl chloride ceased, the mixture was cooled, taken up in ether (250 ml), washed with aqueous sodium bicarbonate, dried and evaporated. Unreacted triethyl phosphite was removed in vacuo, and the crude product was used in the next step without further purification.

المصدر